The only direct flight available between the two cities will operate twice per week, on Monday and Thursday, according to the Dominican low-cost airline.
The inaugural flight on the new route will take off on November 17 and tickets will continue being sold for weekend-only travel through April 28 of next year
During the first year, the carrier expects to transport some 31,000 passengers between Miami and Santa Marta, which it has named its third hub in Colombia.